We compared the top 9 tools that deliver AS2 support based on their pricing, key features and deployment options:
Vendors | Rating | Free trial | Employee size | Starting price |
|---|---|---|---|---|
4.6 based on 36 reviews | ✓ | 533 | $4,299 (one time) | |
4.6 based on 281 reviews | ✓ | 90 | $199/month | |
Cleo Integration Cloud | 4.4 based on 631 reviews | ✕ | 482 | Not shared publicly |
GoAnywhere MFT | 4.8 based on 125 reviews | ✓ | 201-500 | Not shared publicly |
Kiteworks | 4.4 based on 119 reviews | ✓ | 500-1K | $25.5/month |
GlobalSCAPE Enhanced File Transfer | 4.5 based on 118 reviews | ✓ | 1,741 | Not shared publicly |
Axway B2Bi | 4.5 based on 99 reviews | ✓ | 90 | Not shared publicly |
Aayu Technologies AS2 Gateway | 4.2 based on 3 reviews | ✓ | 11-50 | $59/month |
Mendelson AS2 | N/A | Open-source | N/A | Open-source |
The table is sorted based on the number of reviews. Our subscribers are listed at the top.
AS2 software feature comparison
Top 9 AS2 software compared
JSCAPE MFT
JSCAPE MFT Server’s AS2 implementation has been Drummond-certified since 2015. It supports synchronous or asynchronous MDN, and OFTP2 runs on the same server.
AS2 sends and receives can be chained into its low-code Triggers workflows, for example to pull files from remote SFTP servers and forward them to an AS2 partner.
Files.com
Files.com AS2 runs as a cloud service and is configured through stations and partners, which can be managed via API or infrastructure-as-code. Each partner has its own MDN validation level, signature validation level and an option to route outbound connections through the site’s dedicated IPs.
The AS2 log records per-message results for the receipt, decryption, and verification of the digital signature of the file, along with sending back an MDN. These logs are kept for 30 days.
Cleo Integration Cloud
Cleo’s AS2 supports the optional Drummond profiles AS2 Reliability, AS2 Restart, Filename Preservation with MDN Notification (FN-MDN).
AS2 Reliability handles duplicate detection and retries, AS2 Restart resumes interrupted large transfers, and FN-MDN carries the original filename through to the receipt. MDNs can be returned synchronously or asynchronously per partner.
Files received over AS2 can go straight into Cleo’s EDI translation and ERP, TMS, or WMS integrations in the same platform. It can be deployed in the cloud or on-premises.
GoAnywhere MFT
GoAnywhere’s AS2 is Version 1.2 compliant and conforms with the RFC 4130 standard, and the product is Drummond-certified for both AS2 and AS4. It supports multiple file attachments per message. Outbound receipts are returned through synchronous connections. The AS2 server adds automatic/manual MDN approval. On a broken connection, the client will automatically reconnect to the server and retransmit the message.
Kiteworks
Kiteworks lists AS2 alongside SFTP and FTPS in its MFT module. Transfers run inside the same platform as its file sharing, email and web forms, so all of them share one audit log and one set of access policies.
All components run in a hardened virtual appliance that closes unused ports and separates traffic between tiers. Transferred files can be scanned with ICAP-based DLP, the built-in antivirus, and third-party sandboxing (ATP) and content disarm (CDR) tools. Transfers can be started with scheduling, polling, or events, or start them manually.
Globalscape EFT
GlobalSCAPE EFT’s AS2 is an add-on module for Enhanced File Transfer (EFT) Enterprise. It sends and receives AS2 over HTTP or HTTPS and supports resume of partial transfers, integrity checking, message signing, MDN receipts, and Non-Repudiation of Receipt (NRR).
Outbound sends can be triggered from hot folders, scheduled events or custom triggers. Transactions are tied to partner profiles rather than separate event rules. The module includes connection-test tools, transaction monitoring and reports that record the time of transmission and the sender identity.
Axway B2Bi
Axway B2Bi holds Drummond certification for AS2, AS4, and ebMS interoperability. It also supports EDIINT AS1 and AS3, RosettaNet RNIF and OFTP.
AS2 is one transport within a full B2B gateway that includes EDI mapping, content-based routing, and partner self-service onboarding with SLA tracking. It suits organizations consolidating several B2B protocols and translation in one system, but it is heavier than a standalone AS2 server.
Aayu Technologies AS2 Gateway
AS2 Gateway is a dedicated AS2 server. Its key features include AS2 restart to support very large file (VLF) transfers and multiple AS2 identities (stations).
It also supports a custom Message-ID suffix and per-partner suspension of inbound and outbound traffic. A regulatory connector correlates messages exchanged with the FDA and EMA, which is the main reason it appears in life-sciences submissions.
Mendelson AS2
Mendelson AS2 is available as a free GPL community edition and as a commercial client-server edition. All editions support sync and async MDN, AS2 1.2 multiple attachments, and certificate exchange messages (CEM).
Commercial tiers add OAUTH2 for HTTP/S and SMTP and HSM support. The Enterprise HA tier adds clustering, where all nodes share one external database.
What are the features of AS2 Software Solutions?
FAQs
AS2 software tools are instrumental in revolutionizing B2B communications, providing a high-quality, secure, and reliable method for exchanging sensitive information over the internet. These tools are built on the robust foundation of HTTP/HTTPS protocols, guaranteeing a seamless and high-quality data transmission process.
AS2 was initially designed for the exchange of structured business documents, particularly Electronic Data Interchange (EDI) files. However, the AS2 specification does not limit itself to any specific file content. Businesses across various industries and sizes utilize AS2 for exchanging a wide range of file types, including XML, JSON, CSV, flat files, text files, and images, in addition to traditional EDI files.
AS2 is a secure file transfer protocol that uses S/MIME for digital encryption, signatures, and non-repudiation. Unlike traditional FTP, SFTP, or FTPS, it operates over HTTP and HTTPS. AS2 is commonly used to exchange files such as EDI files (e.g., X12 or EDIFACT) and other formats, including XML, JSON, CSV, flat files, text files, images, and binary files. It ensures file security through encryption and verifies authenticity via digital signatures. Additionally, signed receipts issued by the recipient provide legally valid evidence of non-repudiation. Similarly, the OFTP2 protocol is designed for secure data exchange, particularly in the automotive industry, and supports features like file compression, encryption, and digital signatures.
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@misc{dilmegani2026,
author = {Dilmegani, Cem and Ermut, Sıla},
title = {{Top 9 AS2 Software}},
year = {2026},
month = jan,
howpublished = {\url{https://aimultiple.com/as2-software}},
note = {AIMultiple. Retrieved January 12, 2026}
}Results and timestamps of 24 data points. Download the summary data shown in this article's charts and tables as a ZIP file containing 3 CSV files.
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Changelog
12 updatesAdded Files.com to the list of AS2 software.
Cem's work at AIMultiple has been cited by leading global publications including Business Insider, Forbes, Morning Brew, and Washington Post, global firms like Deloitte and HPE, NGOs like World Economic Forum, and supranational organizations like European Commission. [1], [2], [3], [4], [5]
Throughout his career, Cem served as a tech consultant, tech buyer and tech entrepreneur. He advised enterprises on their technology decisions at McKinsey & Company and Altman Solon for more than a decade. He also published a McKinsey report on digitalization.
He led technology strategy and procurement of a telco while reporting to the CEO. He has also led commercial growth of deep tech company Hypatos that reached a 7 digit annual recurring revenue and a 9 digit valuation from 0 within 2 years. Cem's work in Hypatos was covered by leading technology publications like TechCrunch and Business Insider.
Cem regularly speaks at international technology conferences. He graduated from Bogazici University as a computer engineer and holds an MBA from Columbia Business School.
She previously worked as a recruiter in project management and consulting firms. Sıla holds a Master of Science degree in Social Psychology and a Bachelor of Arts degree in International Relations.
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